Dr. Bruce Aylward, WHO Assistant Director-General for Polio, Emergencies and Country Collaboration, told a news conference in Geneva: “What we are seeing today in contrast to previous Ebola outbreaks [are] multiple hotspots within these countries, not a single remote forested area, the kind of environments in which it has been tackled in the past. And then not just multiple hotspots within one country, but international disease, and it is now, as you know, really a multinational effort, three countries, heavily affected.”According to the Ebola response roadmap launched by Dr. Aylward, the key milestones are to “reverse the trend in new cases and infected areas within three months, stop transmission in capital cities and major ports, and stop all residual transmission with 6 to 9 months.”The roadmap “responds to the urgent need to dramatically scale up the international response,” WHO said in a statement. “Nearly 40 per cent of the total number of reported cases have occurred within the past three weeks.”“The $490 million indicative budget for the roadmap presents a consolidated view of the estimated global resources required over the next six months – by national governments, WHO, some UN agencies and other partners – for the health response to stop Ebola transmission,” according to the 27-page document issued by the Geneva-based UN health agency. Priority is being given to needs for treatment and management centres, social mobilization, and safe burials, it said. The latest official number of Ebola virus disease (EVD) cases in Guinea, Liberia, Nigeria, and Sierra Leone stands at 3,069, with over 1,552 deaths, making this the largest Ebola outbreak ever recorded, WHO says. An unprecedented number of health care workers have also been infected and died due to this outbreak.According to the latest West African update, “the overall case fatality rate is 52 per cent. It ranges from 42 per cent in Sierra Leone to 66 per cent in Guinea.” A separate outbreak of Ebola virus disease, which is not related to the outbreak in West Africa, was laboratory-confirmed on 26 August in the Democratic Republic of Congo (DRC).In that update, WHO reiterated that it “does not recommend any travel or trade restrictions be applied except in cases where individuals have been confirmed or are suspected of being infected with EVD or where individuals have had contact with cases of EVD.The WHO roadmap issued today “assumes that in many areas of intense transmission the actual number of cases may be 2-4 fold higher than that currently reported. It acknowledges that the aggregate case load of EVD could exceed 20,000 over the course of this emergency.”The plan “recognizes that a number of currently unaffected countries could be exposed to EVD (Ebola Virus Disease), but assumes that the emergency application of the standard control strategies will stop any new transmission within 8 weeks of the index case.”The roadmap was based on comments received from a large number of partners, including health officials in the affected countries, the African Union, development banks, other UN agencies, Médecins Sans Frontières (MSF), and countries providing direct financial support, WHO said.A situation reports map is expected to begin this week containing hotspots and hot zones, present epidemiological data showing how the outbreak is evolving over time, and communicate what is known about the location of treatment facilities and laboratories, together with data needed to support other elements of the roadmap. Today’s Ebola response roadmap covers the health dimensions of the international response. These dimensions include key potential bottlenecks requiring international coordination, such as the supply of personal protective equipment, disinfectants, and body bags.The roadmap will be complemented by the development of a separate UN-wide operational platform that brings in the skills and capacities of other agencies, including assets in the areas of logistics and transportation. The UN-wide platform aims to facilitate the delivery of essential services, such as food and other provisions, water supply and sanitation, and primary health care.WHO also said today that it continues to monitor for reports of rumoured or suspected cases from countries around the world and systematic verification of these cases is ongoing. Countries are encouraged to continue engaging in active surveillance and preparedness activities, the healthy agency recommended.Dr. Margaret Chan, the WHO Director-General, and Dr. David Nabarro, the UN System Coordinator for Ebola who just completed a visit to the affected countries, are expected to be at UN Headquarters in New York next week, a UN spokesperson said.