The Children Never Had Covid. So Why Did They Have Coronavirus Antibodies?

first_imgThen why do we have a pandemic? Shouldn’t most of us be protected by memory cells left by other coronavirus infections? – Advertisement – Now the researchers are planning to expand their study to monitor thousands of children and adults. Some have antibodies that can block the new coronavirus in lab tests. Others do not.“If they have the pandemic strain, are they protected?” Dr. Kassiotis asked. Will they get sick, he wondered, or will the infection be all but undetectable?Dr. Elledge and his colleagues at Harvard developed their own highly specific, sensitive and exhaustive antibody test, VirScan. It is able to detect a diverse collection of antibodies with that are directed at any of more than 800 places on the new coronavirus, including the antibody that Dr. Kassiotis and his colleagues studied.After examining blood taken from 190 people before the pandemic emerged, Dr. Elledge and his colleagues concluded that many already had antibodies, including the one targeting the base of the spike — presumably from infections with related coronaviruses that cause colds.But while adults might get one or two colds a year, Dr. Elledge said, children may get up to a dozen. As a result, many develop floods of coronavirus antibodies that are present almost continuously; they may lessen cold symptoms, or even leave children with colds that are symptomless but still infectious.While adults may not have detectable coronavirus antibodies, many may be able to quickly make antibodies if they are infected with a coronavirus.In typical viral infections, the immune system pours out antibodies to fight the virus. When the infection is quelled, the antibodies, no longer needed, diminish in number. But the body is left with so-called memory cells that allow antibody production to soar rapidly if the virus tries to invade again. The Coronavirus Outbreak ›Words to Know About TestingConfused by the terms about coronavirus testing? Let us help: In a study published Friday in Science, the group, led by George Kassiotis, who heads the Retroviral Immunology Laboratory at the institute, reports that on average only 5 percent of adults had these antibodies, but 43 percent of children did.Researchers who did not participate in the study were intrigued by the finding. H. Benjamin Larman, an immunologist at Johns Hopkins School of Medicine, called it a “well-done study that puts forward a compelling theory which is supported by their data.” While the tip of the spike is unique to the new coronavirus, the base is found in all coronaviruses, Dr. Kassiotis said. In lab tests, antibodies to the base of the spike prevented the new coronavirus from entering cells in order to reproduce. Stephen J. Elledge, a genetics professor at Harvard Medical School and Brigham and Women’s Hospital, had a similar response. He and others have found many people have antibodies to common colds caused by other coronaviruses; in laboratory studies, these antibodies also block the new coronavirus.- Advertisement –center_img In March, as the pandemic was just beginning, Dr. Kassiotis and his colleagues decided to develop a highly sensitive antibody test. To assess it, they examined blood samples taken before the pandemic from over 300 adults and 48 children and adolescents, comparing them with samples from more than 170 people who had been infected with the new coronavirus.The scientists expected samples taken before the pandemic to have no antibodies that attacked the new coronavirus. Those were to be the controls for the test the scientists were developing.Instead, they found that many children, and some adults, carried one antibody in particular that can prevent coronaviruses, including the new one, from entering cells. This antibody attaches itself to a spike that pokes out of coronaviruses.- Advertisement – “It is quite possible that you lose your memory over time,” Dr. Elledge said. He suspects that the new coronavirus may interfere with the activation of the memory cells able to respond to the infection.An infection “might give you a hazy memory that fades over time,” he said. If so, a very recent infection with a common cold coronavirus would be needed to protect against the new coronavirus, and even then the protection might last only for a limited time.The new coronavirus would have hobbled the production of antibodies that specifically attack it. That might explain why children, with their seemingly continuous colds, are much better off than adults.Dr. Elledge said that if he is right about the loss of memory cells, that bodes well for vaccines. A vaccine boosts antibody production without the presence of a virus. So the virus “is not in the background, messing up memory cell formation,” he said.Another possibility is that most adults actually are protected by memory cells from previous infections with the common cold. Although few have enough antibodies in their blood to protect them at any given time, they may be able to quickly make antibodies to lessen the impact of the new coronavirus.That might explain why many adults who are infected recover quickly.“We focus on those who get really sick, but 95 to 98 percent of those who get the virus don’t have to go to the hospital,” Dr. Elledge said. “There are a lot of people who do get better.” Antibody: A protein produced by the immune system that can recognize and attach precisely to specific kinds of viruses, bacteria, or other invaders.Antibody test/serology test: A test that detects antibodies specific to the coronavirus. Antibodies begin to appear in the blood about a week after the coronavirus has infected the body. Because antibodies take so long to develop, an antibody test can’t reliably diagnose an ongoing infection. But it can identify people who have been exposed to the coronavirus in the past.Antigen test: This test detects bits of coronavirus proteins called antigens. Antigen tests are fast, taking as little as five minutes, but are less accurate than tests that detect genetic material from the virus.Coronavirus: Any virus that belongs to the Orthocoronavirinae family of viruses. The coronavirus that causes Covid-19 is known as SARS-CoV-2. Covid-19: The disease caused by the new coronavirus. The name is short for coronavirus disease 2019.Isolation and quarantine: Isolation is the separation of people who know they are sick with a contagious disease from those who are not sick. Quarantine refers to restricting the movement of people who have been exposed to a virus.Nasopharyngeal swab: A long, flexible stick, tipped with a soft swab, that is inserted deep into the nose to get samples from the space where the nasal cavity meets the throat. Samples for coronavirus tests can also be collected with swabs that do not go as deep into the nose — sometimes called nasal swabs — or oral or throat swabs.Polymerase Chain Reaction (PCR): Scientists use PCR to make millions of copies of genetic material in a sample. Tests that use PCR enable researchers to detect the coronavirus even when it is scarce.Viral load: The amount of virus in a person’s body. In people infected by the coronavirus, the viral load may peak before they start to show symptoms, if symptoms appear at all. That happened to Dr. Larman and his family of five. Four of them got sick with Covid-19, the illness caused by the new coronavirus, in July. None were seriously ill, and his 4-year-old son was spared altogether.“My son was not isolated from us and therefore heavily exposed,” Dr. Larman said. “He tested negative twice, and so we certainly suspect that he had some form of pre-existing immunity.” It’s been a big puzzle of the pandemic: Why are children so much less likely than adults to become infected with the new coronavirus and, if infected, less likely to become ill?A possible reason may be that many children already have antibodies to other coronaviruses, according to researchers at the Francis Crick Institute in London. About one in five of the colds that plague children are caused by viruses in this family. Antibodies to those viruses may also block SARS-CoV-2, the new coronavirus causing the pandemic.- Advertisement –last_img read more

Chris Paul in ‘great rhythm’ as Clippers near playoffs

first_imgOf course, the Clippers lost to the Jazz in a game that had significant playoff ramifications. The Clippers fell two games behind the Jazz for fourth in the West. While Utah remains the Clippers’ likely first-round opponent, Oklahoma City entered Tuesday just two games back of L.A. for fifth.Paul wasn’t interested Monday in discussing his offense. Instead, he was kicking himself for letting George Hill, Utah’s point guard, get free for 19 points.“Offense is what it is, but I go into every game thinking about defense,” Paul said.If the nine-time All-Star is rounding into form at the right time, Paul is still waiting for the rest of the Clippers to catch up. L.A. is 5-6 since the All-Star break.“We’ve got to get it together,” Paul said. “I’d much rather be playing together and playing consistently on both ends and lose a couple games and know that we have our principles, but we’re still working on it.”Injuries have knocked the Clippers behind schedule on that front.“It sucks,” Paul said, “but you’ve got to do it. If we were ready for everything right now, we might be peaking too soon, so hopefully we hit it at the right time.” Newsroom GuidelinesNews TipsContact UsReport an Error “I think he’s in great rhythm right now,” coach Doc Rivers said in Salt Lake City. “I thought tonight we needed him to do that. Some night we need him to just be a playmaker, some nights we need him to be a scorer.”Rivers often finds himself imploring Paul to be more assertive when it comes to his own shot.“I let Chris be Chris,” Rivers said, “but at the end of the day when he’s not, we have to tell him. Because he’s such a willing passer, sometimes he can forget about what he can do well, and we need him to do it more.”Against the Jazz, Paul may have been at his scoring best. He racked up 16 points in the first half. And his 21 shots for the game were his second-most this year, behind only the 26 attempts he hoisted in a double-overtime loss at Brooklyn in November.“I think when he’s assertive we’re a better basketball team,” Rivers said.center_img After one layup with a high degree of difficulty, Chris Paul headed the ball as it fell through the net as though he were in a soccer match. On the next Clippers possession, he ran right up to the 3-point line and fired a shot that swished through.He wasn’t looking for anyone but himself. He was feeding the hot hand, who just happened to be himself.The constant push-pull of Chris Paul is whether he is at his best for the Clippers when he is looking for his own shot or setting up others. One of the best passing guards in the game, he is also a uniquely skilled shot maker.Paul’s scoring ability has been on the forefront of late. He scored 33 points in Monday’s 114-108 loss at Utah, and has totaled 82 points in his past three games.last_img read more

L.A. Times parent mulls offer from Chicago mogul

first_imgCHICAGO – The Tribune Co. board of directors is considering an offer from real estate magnate Sam Zell to take the company private, but is leaning toward restructuring the company on its own, according to published reports. The company, whose properties include the Los Angeles Times, appointed a special board committee in September to review prospective offers. Pressured by a long-slumping stock price, the board intends to decide on a plan to increase shareholder value by the end of March, company officials said. The board would prefer recapitalization involving a spinoff of Tribune’s television stations and the payment of a bid dividend to shareholders, The Wall Street Journal reported Sunday on its Web site. The proposal from Chicago-based Zell would involve buying the entire company with participation from an employee stock ownership plan, The New York Times reported for today’s editions. The deal would be highly leveraged, but employee stock plans have many tax advantages, including the ability to write off interest on debt, the Times reported. Zell’s spokeswoman did not return calls Sunday to The Associated Press; nor did Tribune spokesman Gary Weitman. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!last_img read more