The Children Never Had Covid. So Why Did They Have Coronavirus Antibodies?

first_imgThen why do we have a pandemic? Shouldn’t most of us be protected by memory cells left by other coronavirus infections? – Advertisement – Now the researchers are planning to expand their study to monitor thousands of children and adults. Some have antibodies that can block the new coronavirus in lab tests. Others do not.“If they have the pandemic strain, are they protected?” Dr. Kassiotis asked. Will they get sick, he wondered, or will the infection be all but undetectable?Dr. Elledge and his colleagues at Harvard developed their own highly specific, sensitive and exhaustive antibody test, VirScan. It is able to detect a diverse collection of antibodies with that are directed at any of more than 800 places on the new coronavirus, including the antibody that Dr. Kassiotis and his colleagues studied.After examining blood taken from 190 people before the pandemic emerged, Dr. Elledge and his colleagues concluded that many already had antibodies, including the one targeting the base of the spike — presumably from infections with related coronaviruses that cause colds.But while adults might get one or two colds a year, Dr. Elledge said, children may get up to a dozen. As a result, many develop floods of coronavirus antibodies that are present almost continuously; they may lessen cold symptoms, or even leave children with colds that are symptomless but still infectious.While adults may not have detectable coronavirus antibodies, many may be able to quickly make antibodies if they are infected with a coronavirus.In typical viral infections, the immune system pours out antibodies to fight the virus. When the infection is quelled, the antibodies, no longer needed, diminish in number. But the body is left with so-called memory cells that allow antibody production to soar rapidly if the virus tries to invade again. The Coronavirus Outbreak ›Words to Know About TestingConfused by the terms about coronavirus testing? Let us help: In a study published Friday in Science, the group, led by George Kassiotis, who heads the Retroviral Immunology Laboratory at the institute, reports that on average only 5 percent of adults had these antibodies, but 43 percent of children did.Researchers who did not participate in the study were intrigued by the finding. H. Benjamin Larman, an immunologist at Johns Hopkins School of Medicine, called it a “well-done study that puts forward a compelling theory which is supported by their data.” While the tip of the spike is unique to the new coronavirus, the base is found in all coronaviruses, Dr. Kassiotis said. In lab tests, antibodies to the base of the spike prevented the new coronavirus from entering cells in order to reproduce. Stephen J. Elledge, a genetics professor at Harvard Medical School and Brigham and Women’s Hospital, had a similar response. He and others have found many people have antibodies to common colds caused by other coronaviruses; in laboratory studies, these antibodies also block the new coronavirus.- Advertisement –center_img In March, as the pandemic was just beginning, Dr. Kassiotis and his colleagues decided to develop a highly sensitive antibody test. To assess it, they examined blood samples taken before the pandemic from over 300 adults and 48 children and adolescents, comparing them with samples from more than 170 people who had been infected with the new coronavirus.The scientists expected samples taken before the pandemic to have no antibodies that attacked the new coronavirus. Those were to be the controls for the test the scientists were developing.Instead, they found that many children, and some adults, carried one antibody in particular that can prevent coronaviruses, including the new one, from entering cells. This antibody attaches itself to a spike that pokes out of coronaviruses.- Advertisement – “It is quite possible that you lose your memory over time,” Dr. Elledge said. He suspects that the new coronavirus may interfere with the activation of the memory cells able to respond to the infection.An infection “might give you a hazy memory that fades over time,” he said. If so, a very recent infection with a common cold coronavirus would be needed to protect against the new coronavirus, and even then the protection might last only for a limited time.The new coronavirus would have hobbled the production of antibodies that specifically attack it. That might explain why children, with their seemingly continuous colds, are much better off than adults.Dr. Elledge said that if he is right about the loss of memory cells, that bodes well for vaccines. A vaccine boosts antibody production without the presence of a virus. So the virus “is not in the background, messing up memory cell formation,” he said.Another possibility is that most adults actually are protected by memory cells from previous infections with the common cold. Although few have enough antibodies in their blood to protect them at any given time, they may be able to quickly make antibodies to lessen the impact of the new coronavirus.That might explain why many adults who are infected recover quickly.“We focus on those who get really sick, but 95 to 98 percent of those who get the virus don’t have to go to the hospital,” Dr. Elledge said. “There are a lot of people who do get better.” Antibody: A protein produced by the immune system that can recognize and attach precisely to specific kinds of viruses, bacteria, or other invaders.Antibody test/serology test: A test that detects antibodies specific to the coronavirus. Antibodies begin to appear in the blood about a week after the coronavirus has infected the body. Because antibodies take so long to develop, an antibody test can’t reliably diagnose an ongoing infection. But it can identify people who have been exposed to the coronavirus in the past.Antigen test: This test detects bits of coronavirus proteins called antigens. Antigen tests are fast, taking as little as five minutes, but are less accurate than tests that detect genetic material from the virus.Coronavirus: Any virus that belongs to the Orthocoronavirinae family of viruses. The coronavirus that causes Covid-19 is known as SARS-CoV-2. Covid-19: The disease caused by the new coronavirus. The name is short for coronavirus disease 2019.Isolation and quarantine: Isolation is the separation of people who know they are sick with a contagious disease from those who are not sick. Quarantine refers to restricting the movement of people who have been exposed to a virus.Nasopharyngeal swab: A long, flexible stick, tipped with a soft swab, that is inserted deep into the nose to get samples from the space where the nasal cavity meets the throat. Samples for coronavirus tests can also be collected with swabs that do not go as deep into the nose — sometimes called nasal swabs — or oral or throat swabs.Polymerase Chain Reaction (PCR): Scientists use PCR to make millions of copies of genetic material in a sample. Tests that use PCR enable researchers to detect the coronavirus even when it is scarce.Viral load: The amount of virus in a person’s body. In people infected by the coronavirus, the viral load may peak before they start to show symptoms, if symptoms appear at all. That happened to Dr. Larman and his family of five. Four of them got sick with Covid-19, the illness caused by the new coronavirus, in July. None were seriously ill, and his 4-year-old son was spared altogether.“My son was not isolated from us and therefore heavily exposed,” Dr. Larman said. “He tested negative twice, and so we certainly suspect that he had some form of pre-existing immunity.” It’s been a big puzzle of the pandemic: Why are children so much less likely than adults to become infected with the new coronavirus and, if infected, less likely to become ill?A possible reason may be that many children already have antibodies to other coronaviruses, according to researchers at the Francis Crick Institute in London. About one in five of the colds that plague children are caused by viruses in this family. Antibodies to those viruses may also block SARS-CoV-2, the new coronavirus causing the pandemic.- Advertisement –last_img read more

USG senators criticize Shapiro event funding

first_imgAt Tuesday’s Undergraduate Student Government meeting, the Senate led an open discussion regarding the recent bylaw amendment to USG’s diversity fund, which is currently being authored by Sen. Michaela Murphy and former USG official Mai Mizuno. Before the discussion, co-Chief Diversity Officer Milton Dimas spoke about a solidarity march this Thursday and how it was happening due to the “many, many problems in this institution” and the country at large. Dimas concluded his speech by addressing an upcoming event featuring conservative commentator Ben Shapiro. He called Shapiro’s rhetoric “hate speech” and “bigotry,” and affirmed the student body’s right to speak out. “Many of us are unhappy about [Shapiro’s speech], and I understand,” Dimas said. “I don’t think that we should remain silent during this time. I believe we should very much be using our resources and the people we know in order to bring about this change.” Regarding the diversity fund, Sen. Shayan Kohanteb addressed Dimas’ comments on Shapiro’s event, which received funding from USG. Kohanteb said that USG funds should not be used for political groups. His point prompted a discussion about whether or not cultural organizations and the issues they promote can be depoliticized. Sen. Max Geschwind said that he had no problem with political groups receiving funding as long as the process is “fair and equal.” He referenced groups such as Students for Justice in Palestine and Trojans for Israel, who he says should receive an equal share of the diversity fund. Several members of the audience expressed their opinions that the interests of cultural organizations are inherently political, and that diminishing their political nature would devalue the organizations’ purposes.Rosa Wang, executive co-director of the Student Assembly for Gender Empowerment, defended the inherently political nature of their organization. She and others also referred to Shapiro’s views as hateful. Wang went on to call the use of a student-funded account for the event as “blasphemy.”“I never asked to be marginalized,” Wang said. “The people who attribute those values to me have made my body political, have made me have to fight for myself, fight for my existence.”last_img read more